Rodent Research Technician - Level 2

Transpharmation is a dynamic preclinical contract research organization that specializes in high-quality, translational drug discovery services. The company provides a friendly and team-oriented work atmosphere as well as competitive wages and benefits.

The Research Technician II (“RT II”) will have a solid understanding of each individual’s roles and responsibilities within the company and within research studies. The RT II will have a clear understanding of and be able to perform a majority of the procedures at Transpharmation Canada within the Rodent Department. The RT II will demonstrate a clear understanding of the complexities of a research trial and be able to efficiently follow study protocols, with continued guidance from the Study Coordinator/Study Director/Scientific Director.

Duties and Responsibilities

• Key Activities Assist and perform assigned in vivo study procedures in the Rodent Department.
• Act as study personnel in OECD GLP studies.
• Record and document experimental details with a high level of integrity, ethics and accuracy in adherence with Good Documentation Practice.
• Assist in the preparation of data summary reports, study related data entry, Quality Control.
• Perform study-related husbandry duties to ensure proper animal care practices are adhered to and are according to CCAC guidelines and facility SOPs.
• Work within a team to ensure that projects are successfully conducted and completed to a high level of quality and scientific competence.
• Participate in the maintenance of an adequate inventory of supplies.
• Assist the Rodent Department Manager in the maintenance and operation of animal facility and husbandry in accordance with CCAC guidelines, Animals for Research Act and facility SOPs Participate in internal working groups (eg. animal care committee, health and safety, etc).
• Demonstrate and/or train processes and techniques to new employees and visitors.
• Other duties as assigned

Duties

associated with the Rodent Wing General techniques: Operate centrifuges and perform advanced blood separation Proficient handling and restraint of rodents Health Observations (daily observations, endpoint monitoring) Drug administrations (SC, IM, IP, IV, PO, IN, intradermal, etc.) Survival blood collection (saphenous, tail snip, submandibular, catheter, etc.) Terminal blood collection, tissue/organ extraction and weighing Anaesthesia/Analgesia in support of surgery and animal welfare Euthanasia Seizure Testing: Perform and/or support seizure testing, including but not limited to: MES 6Hz Corneal Kindling Amygdala Kindling Pain Testing: Perform and/or support pain testing from start to end independently, including but not limited to: Von Frey Acetone drop Tail flick Formalin Behavioral testing: Prepare rooms and supplies for testing Possess ability to operate test apparatus for behavioral and cognitive testing (LMA, rotarod, grip strength, core body temperature, watermaze, running wheel, PPI, Moseq, as well as software application as it relates to the test,etc.) Various behavioural assessments and scoring EEG systems: DSI and TaiNi Operant testing (as applicable): Possess ability to independently run operant training and testing, as assigned and scheduled by Study Coordinator Rodent Abuse Liability (as applicable): General Behavioural Assessments Place Conditioning IV and Oral Self-administration Dependence and withdrawal assessment Basic formulation skills Surgery support, recovery, and endpoint monitoring Basic surgery skills IV catheter and osmotic pump implant care and maintenance Working with controlled substances Data Management: Ability to create basic graphs from experimental results Understand basic data analysis (means, standard error, median, interquartile) Any other duties as deemed necessary